 | - Crops of macules that become papules, then vesicles that evolve into crusted pustules. Lesions are present in all stages of evolution
- Lesions most prominent on the trunk; head, extremities, and mucous membranes also involved
- Eruption is pruritic
- Rash occurs after a prodrome of chills, fever, malaise, headache, sore throat and dry cough
- Tzanck smear taken from the base of a vesicle shows characteristic multinucleate giant cells
- See Herpes Zoster Infection for an example of a positive Tzanck smear, and for characteristic histopathology
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