Indiana University

Lupus Erythematosus, Discoid
  • Red plaques with expanding inflammatory border and central hypopigmented atrophic scar
  • Lesions may occur anywhere but are most commonly seen in areas exposed to sunlight such as the face, ears, neck and scalp
  • This form of lupus erythematosus is usually not associated with systemic manifestations, however approximately 5% of patients with discoid lupus erythematosus eventually develop systemic lupus erythematosus
  • Immunoglobulins are deposited along the basement membrane of involved skin
  • Histology: Hyperkeratosis, follicular plugging, epidermal atrophy alternating withacanthosis, basal vacuolization, papillary dermal edema, perivascular and periadnexal infiltrate of lymphocytes, glycosaminoglycans (mucin) deposition in the dermis.

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