Indiana University

Herpes Zoster Infection
  • Groups of vesicles arranged along the distribution of a cranial or spinal nerve
  • Cutaneous and visceral dissemination from the original dermatome develops in some individuals, particularly immunocompromised patients
  • Associated with localized or referred pain
        • Examination of material from the base of the vesicle (Tzanck preparation) will show characteristic multinucleate giant cells
        • Histology: Intraepidermal vesicles with diagnostic multinucleate giant cells in adjacent epidermis or adnexal structures

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