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The corresponding alcohol-fixed, Papanicolaou stained slides show many cohesive small and large clusters of tumor cells. The cytoplasmic difference between the tumor cells and hepatocytes from the surrounding liver is even more apparent with alcohol-fixed preparations than on air-dried slides. The ovoid or elongated nuclei of colon carcinoma show striking darkness of the nuclear staining (hyperchromasia). Occasional parallel columnar cells can be found on these slides as on air-dried slides. If there are fewer lesions in the liver and they are in locations accessible to partial hepatectomy, resection of such metastatic disease has resulted in long term survival in about 25% of patients.
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