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Fine needle aspiration of metastatic colon carcinoma yields many cell clusters which are clearly distinct from hepatocytes. The metastatic tumor cells have clear or vacuolated cytoplasm rather than the granular, dense cytoplasm of hepatocytes. In Diff-Quik stained, air-dried preparations used for rapid interpretation in the Radiology Department, parallel "picket fence" rows of elongated columnar-cell nuclei are often seen. This finding usually causes the Cytopathologist to suspect metastatic colon carcinoma.
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